The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world and the largest commitment by any nation to combat a single disease internationally. PEPFAR is improving the availability of mapping data in areas affected by the HIV/AIDS epidemic in its program areas by leveraging resources and partnerships through YouthMappers. Students contributed to this open data initiative by mapping population clusters and to help program coordinators understand where communities are located and connected, a key component in determining if HIV/AIDS services are in the right place. Ultimately, the emerging data supports understanding of PEPFAR program coverage, optimization of supply chain logistics, and analyses of clinical site-level data. In particular YouthMappers also focused on the DREAMS project, which supports girls and women under this campaign.